Molecular line emissions offer researchers exciting opportunities to learn about the evolutionary state of the Milky Way and distant galaxies. This text provides a detailed introduction to molecular astrophysics and an array of useful techniques for observing astronomical phenomena at millimetre and submillimetre wavelengths. After discussing the theoretical underpinnings of molecular observation, the authors catalogue suitable molecular tracers for many types of astronomical regions in local and distant parts of the Universe, including cold gas reservoirs primed for the formation of new stars, regions of active star formation, giant photon-dominated regions and near active galactic nuclei. Further chapters demonstrate how to obtain useful astronomical information from raw telescope data while providing recommendations for appropriate observing strategies. Replete with maps, charts and references for further reading, this handbook will suit research astronomers and graduate students interested in broadening their skill to take advantage of the new facilities now coming online.
This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg ´´Hallmarks of Cancer´´ are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book´s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
Recent research in molecular biology has produced a remarkably detailed understanding of how living things operate. Becoming conversant with the intricacies of molecular biology and its extensive technical vocabulary can be a challenge, though, as introductory materials often seem more like a barrier than an invitation to the study of life. This text offers a concise and accessible introduction to molecular biology, requiring no previous background in science, aimed at students and professionals in fields ranging from engineering to journalism--anyone who wants to get a foothold in this rapidly expanding field. It will be particularly useful for computer scientists exploring computational biology. A reader who has mastered the information in The Processes of Life is ready to move on to more complex material in almost any area of contemporary biology.
Presenting an area of research that intersects with and integrates diverse disciplines, including molecular biology, applied informatics, and statistics, among others, Bioinformatics for Omics Data: Methods and Protocols collects contributions from expert researchers in order to provide practical guidelines to this complex study. Divided into three convenient sections, this detailed volume covers central analysis strategies, standardization and data-management guidelines, and fundamental statistics for analyzing Omics profiles, followed by a section on bioinformatics approaches for specific Omics tracks, spanning genome, transcriptome, proteome, and metabolome levels, as well as an assortment of examples of integrated Omics bioinformatics applications, complemented by case studies on biomarker and target identification in the context of human disease. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
This book provides detailed state-of-the-art protocols for analyzing individual aspects of stem cell mobilization at the molecular and cellular level with contributions encompassing the most recent technological developments. Specifically, the volume covers cell adhesion and migration assays in three-dimensional models, imaging techniques for the determination of blood flow or hypoxic status, innovative biomechanical studies of stem cells, and assays to determine the involvement of proteases or complement factors, as well as other key topics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell Mobilization: Methods and Protocols is an ideal guide for all laboratories in their endeavors to decipher the mechanisms of stem cell mobilization, ultimately helping stem cell donors and patients around the world.
Erosive tooth wear is a multifactorial condition of growing concern to the clinician and the subject of extensive research. Since the publication of the first edition of the book with the title Dental Erosion, new knowledge for a better understanding of this important subject has been gathered. The new and more detailed insights resulted in this second, extended publication. It presents a broad spectrum of views, from the molecular level to behavioural aspects, as well as trends in society. In particular, the issues concerning chemical and biological factors as well as dental erosion in children are covered more extensively in this second edition. The first chapters include topics such as the definition, diagnosis, interaction, epidemiology and histopathology of tooth wear. Further, the aetiology of dental erosion, including nutritional and patient-related factors, and dental erosion in children are discussed. This book is a valuable and indispensable guide to better oral health and is highly recommended to faculty members, researchers, dental students, practitioners and other dental professionals.
This book provides detailed information on basic and advanced laboratory techniques in histopathology and cytology. It discusses the principles of and offers clear guidance on all routine and special laboratory techniques. In addition, it covers various advanced laboratory techniques, such as immunocytochemistry, flow cytometry, liquid based cytology, polymerase chain reaction, tissue microarray, and molecular technology. Further, the book includes numerous color illustrations, tables and boxes to familiarize the reader with the work of a pathology laboratory. The book is mainly intended for postgraduate students and fellows in pathology as well as practicing pathologists. The book is also relevant for all the laboratory technicians and students of laboratory technology.
´´ Metabolism of Human Diseases ´´ examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson´s disease, Alzheimer´s disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell disease, hyperlipidemia, fever, sepsis, allergies, peptic ulcer, gastroenteritis, lactose intolerance, colon cancer, diabetes, cirrhosis, metabolic syndrome, hypertension, chronic kidney disease, gout, urinary tract infections, kidney stones, dental caries, osteoporosis, osteoarthritis, rheumatoid arthritis, breast cancer and prostate cancer. The book also describes commonly used drugs and explains their molecular targets. It provides the first comprehensive and detailed summary of the metabolism of individual organs and their physiological and pathological functioning. Thus it serves as a useful supplement to previous textbooks of human physiology. ´´ Metabolism of Human Diseases ´´ is a must-have, state-of-the-art textbook written by International experts for graduate students, postdocs and scientists in metabolic research, biochemistry, physiology and pharmacy as well as for physicians interested in molecular mechanisms underlying common human diseases.
Part 1/3 of Engler´s Syllabus of Plant Families - Basidiomycota and Entorrhizomycota provides a thorough treatise of the world-wide morphological and molecular diversity of the fungal phyla Basidiomycota and Entorrhizomycota. The Basidiomycota (Pucciniomycotina, Ustilaginomycotina, Agaricomycotina) are an extremely diverse group of the fungi with c. 36000 species, with a fascinating range of morphological and biological variation, distributed from the Antarctic, arctic tundra to tropical rainforests, and of high economic value. Many species of Agaricomycotina play a role in human food, most important and of greatest economic interest are the parasitic Pucciniomycotina and Ustilagomycotina. The Entorrhizomycota are plant root associated fungi and seem to represent a lineage of living fossils which links Glomeromycota, Ascomycota and Basidiomycota in a probable common origin. The present volume is, as the formerly published volumes of the Syllabus, an updated synthesis of classical anatomical-morphological characters with modern molecular data, incorporating numerous new discoveries made during the last ten years, providing a comprehensive modern survey covering all families and genera of the Basidiomycota and Entorrhizomycota including detailed family descriptions. Following the tradition of Engler, and incorporating the latest results from molecular phylogenetics and phylogenomics, the completely restructured and revised 13th edition provides an up-to-date evolutionary and systematic overview of the fungal and plant groups. It is a mandatory reference for students, experts and researchers from all fields of biological sciences, particularly botany, phycology and mycology. While the Fungi are not part of the Plant Kingdom, they are formally included within the classic Engler´s title ´´Syllabus der Pflanzenfamilien / Syllabus of Plant Families´´, which comprised families of blue-green algae, algae, fungi, lichens, ferns, gymnosperms and flowering plants.