Travel backward through time from today´s scattered billions to the handful of early humans who lived in Africa 60,000 years ago and are ancestors to us all. In Deep Ancestry , scientist and National Geographic explorer Spencer Wells shows how tiny genetic changes add up over time into a fascinating story. Using scores of real-life examples, helpful analogies, and detailed diagrams and illustrations, he explains exactly how each and every individual´s DNA contributes another piece to the jigsaw puzzle of human history. The book takes readers inside the Genographic Project-the landmark study now assembling the world´s largest collection of DNA samples and employing the latest in testing technology and computer analysis to examine hundreds of thousand of genetic profiles from all over the globe-and invites us all to take part.
Analytics is a vital part of the business world we live in today. Without a detailed analysis of market conditions and other factors it would be impossible to tell if any new venture, whether it be a new business or the revamp of an old one, would be profitable. Data Analytics: Insider´s Guide to Master Data Analytics will help you to better understand the complexities of data analytics. It will show you the benefits it can have for your business and how to make the best decisions. The chapters include detailed information on: The basics of analytics Techniques for data analysis Genetic algorithms Regression analysis Social network analysis And much more... The benefits of understanding data analysis will help your business to prosper and expand in the right directions, cutting down on risk and creating greater profitability. The Insider´s Guide to Master Data Analytics is a book which is thorough and complete, delivering all the information you´ll ever need, in one handy book and providing you with real life examples of those businesses that got it right. Get you copy today and see your business thrive for tomorrow. 1. Language: English. Narrator: Sean Anthony. Audio sample: http://samples.audible.de/bk/acx0/085350/bk_acx0_085350_sample.mp3. Digital audiobook in aax.
This second edition volume expands on the first edition with more detailed methodologies on prenatal testing and diagnosis, and also covers next-generation sequencing techniques. The chapters in this book are divided into three sections: preimplantation genetic testing, traditional prenatal testing, and non-invasive prenatal testing. This book covers topics such as molecular testing for preimplantation genetic diagnosis of single gene disorders; DNA extraction from various types of prenatal specimens; prenatal diagnosis of cystic fibrosis and Tay-Sachs disease; chromosomal SNP microarrays; and isolation of cell-free DNA from maternal plasma. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Prenatal Diagnosis, Second Edition is a valuable resource for any researcher interested in reproducing these techniques in their clinical laboratories.
This grammar is a first detailed description of Qaqet, a non-Austronesian language spoken in the mountainous interior of East New Britain Province, Papua New Guinea. Qaqet belongs to the small Baining language family (comprising six languages), but its wider genetic affiliations remain unclear. It is included among the geographically-defined East Papuan languages. The grammar presents a synchronic description of the language. From a language family perspective, the Baining languages are structurally fairly similar, but there are considerable differences in detail that point to different language-internal developments and grammaticalization paths. From an East Papuan and areal perspective, Qaqet exhibits both typical East Papuan features (e.g., nominal classification, possessor/possessed order, highly compositional lexicon) as well as areal features (e.g., AVO ~ SV constituent order, articles and determiners, prepositions). The description is based on primary data collected during fieldwork (from 2011 onwards), including both natural and elicited data. The description thereby provides new analyses and insights that are relevant to our understanding of the genetic and areal relationships in this region.
This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.
This volume provides detailed descriptions on cutting-edge experimental methods to assess the multiple and complex interactions between T. cruzi and its host. Chapters detail a series of methods and protocols, ranging from rather classical biochemical/genetic approaches to modern, powerful and high-throughput ´-omics´ technologies, to tackle this issue, as well as novel techniques to improve treatment and clinical evaluation of Chagasic patients. Genome-wide mining strategies aimed at identifying potential parasite antigens and vaccine candidates and an overview on the challenges and milestones encountered during T. cruzi genome assembly are also included. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, T. cruzi Infection: Methods and Protocols aims to provide students, researchers, and clinicians who are interested in the study of Chagas disease an indispensable source of information.
Predicting the future for financial gain is a difficult, sometimes profitable activity. The focus of this book is the application of biologically inspired algorithms (BIAs) to financial modelling. In a detailed introduction, the authors explain computer trading on financial markets and the difficulties faced in financial market modelling. Then Part I provides a thorough guide to the various bioinspired methodologies - neural networks, evolutionary computing (particularly genetic algorithms and grammatical evolution), particle swarm and ant colony optimization, and immune systems. Part II brings the reader through the development of market trading systems. Finally, Part III examines real-world case studies where BIA methodologies are employed to construct trading systems in equity and foreign exchange markets, and for the prediction of corporate bond ratings and corporate failures. The book was written for those in the finance community who want to apply BIAs in financial modelling, and for computer scientists who want an introduction to this growing application domain.
This book provides an overview of auto-inflammatory syndromes, covering the underlying immune mechanisms that lead to their development, specific disease presentations, and clinical treatment guidelines. The book is divided into two sections, adult and pediatric, with chapters focusing on individuals diseases such as systemic arthritis, hyper-IgD, pap syndrome, idiopathic recurrent pericarditis, and familial Mediterranean fever. Chapters incorporate the most recent advances in disease pathophysiology and examine the underlying inductive and effector mechanisms and therapies that relate to each auto-inflammatory disorder at the genetic, molecular, cellular, and epidemiologic levels. The book also discusses the research behind auto-inflammatory disorders to offer detailed clinical guidelines regarding diagnostic techniques, treatment plans, and advice on how to best transition pediatric patients into adult treatment. This is an invaluable reference on auto-inflammatory syndromes for clinicians and researchers in pediatric and adult rheumatology and immunology.
Part of the highly regarded Diagnostic Pathology series, this updated volume is a visually stunning, easy-to-use reference covering all aspects of common and rare renal diseases and their variants. Outstanding images-including gross and microscopic pathology, a wide range of stains, and detailed medical illustrations-make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. Written by leading pathologists, this second edition presents an up-to-date , concise presentation of major pathological, clinical, pathophysiological, and genetic information for over 240 diagnoses .
John Butler, bestselling author of Forensic DNA Typing, now applies his expertise on the subject of DNA analysis into an introductory textbook. Fundamentals of Forensic DNA Typing walks students step-by-step through the DNA analysis process beginning with collection of evidence at a crime scene to the statistical interpretation of the results. Also included are brief discussions of such news worthy topics as victim identification from the September 11, 2001 attacks, the identification of the remains of the Romanovs, the last Russian Royal family, and the O.J. Simpson case. New applications, such as genetic genealogy and tracing domestic pet hairs to perpetrators, are also detailed. With its clear and understandable style and extensive list of online ancillaries and study aids, this textbook will make the subject accessible to students in forensic science courses worldwide. Includes a glossary with over 400 terms for quick reference of unfamiliar terms as well as an acronym guide to decipher the DNA dialect Continues in the style of Forensic DNA Typing, 2e, with high-profile cases addressed in D.N.A.Boxes-- ´´Data, Notes & Applications´´ sections throughout Ancillaries include: instructor manual Web site, with tailored set of 1000+ PowerPoint slides (including figures), links to online training websites and a test bank with key